Designing the CORONIS trial. Why a non-regular fractional factorial design?
نویسندگان
چکیده
منابع مشابه
Designing the CORONIS trial. Why a non-regular fractional factorial design?
Introduction Caesarean section is one of the most commonly performed operations worldwide. A variety of surgical techniques for all elements of the operation are used. Many of them have not been rigorously evaluated in randomised controlled trials. The CORONIS Trial set out to simultaneously examine five elements of the caesarean section operation in seven lowto middle-income countries, using a...
متن کاملThe CORONIS Trial. International study of caesarean section surgical techniques: a randomised fractional, factorial trial
BACKGROUND Caesarean section is one of the most commonly performed operations on women throughout the world. Rates have increased in recent years - about 20-25% in many developed countries. Rates in other parts of the world vary widely.A variety of surgical techniques for all elements of the caesarean section operation are in use. Many have not yet been rigorously evaluated in randomised contro...
متن کاملCaesarean section surgical techniques (CORONIS): a fractional, factorial, unmasked, randomised controlled trial
BACKGROUND Variations exist in the surgical techniques used for caesarean section and many have not been rigorously assessed in randomised controlled trials. We aimed to assess whether any surgical techniques were associated with improved outcomes for women and babies. METHODS CORONIS was a pragmatic international 2×2×2×2×2 non-regular fractional, factorial, unmasked, randomised controlled tr...
متن کاملCaesarean section surgical techniques: 3 year follow-up of the CORONIS fractional, factorial, unmasked, randomised controlled trial
BACKGROUND The CORONIS trial reported differences in short-term maternal morbidity when comparing five pairs of alternative surgical techniques for caesarean section. Here we report outcomes at 3 years follow-up. METHODS The CORONIS trial was a pragmatic international 2 × 2 × 2 × 2× 2 non-regular fractional, factorial, unmasked, randomised controlled trial done at 19 sites in Argentina, Chile...
متن کامل2-level Fractional Factorial Designs Which Are the Union of Non Trivial Regular Designs
Every fraction is a union of points, which are trivial regular fractions. To characterize non trivial decomposition, we derive a condition for the inclusion of a regular fraction as follows. Let F =
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ژورنال
عنوان ژورنال: Trials
سال: 2013
ISSN: 1745-6215
DOI: 10.1186/1745-6215-14-s1-o57